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An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones

✍ Scribed by John R. Rizzo; Charles A. Alt; Tony Y. Zhang


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
146 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis


3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec-alkylation products.


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