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Organization of transcriptional regulatory machinery in nuclear microenvironments: Implications for biological control and cancer

✍ Scribed by Gary S. Stein; Jane B. Lian; Andre J. van Wijnen; Janet L. Stein; Amjad Javed; Martin Montecino; Je-Yong Choi; Diana Vradii; Sayyed K. Zaidi; Jitesh Pratap; Daniel Young


Book ID
113418929
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
352 KB
Volume
47
Category
Article
ISSN
0065-2571

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## Abstract The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches

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## Abstract The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised wi