✦ LIBER ✦

Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

✍ Scribed by Gary S. Stein; Sayyed K. Zaidi; Janet L. Stein; Jane B. Lian; Andre J. van Wijnen; Martin Montecino; Daniel W. Young; Amjad Javed; Jitesh Pratap; Je-Yong Choi; Syed A. Ali; Sandhya Pande; Mohammad Q. Hassan

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 456 KB
Volume: 104
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.21813

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment. J. Cell. Biochem. 104: 2016–2026, 2008. © 2008 Wiley‐Liss, Inc.

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