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Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

✍ Scribed by Gary S Stein; Jane B Lian; Janet L Stein; André J van Wijnen; Martin Montecino; Jitesh Pratap; J.e Choi; S.Kaleem Zaidi; Amjad Javed; Soraya Gutierrez; Kimberly Harrington; Jiali Shen; Daniel Young

Book ID
117726500
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
205 KB
Volume
30
Category
Article
ISSN
1079-9796

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## Abstract The osteoclast is a highly polarized multinucleated cell that resorbs bone. Using high resolution immunofluorescence microscopy, we demonstrated that all nuclei of an osteoclast are transcriptionally active. Each nucleus within the osteoclast contains punctately organized microenvironme