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Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer

✍ Scribed by Gary S. Stein; Jane B. Lian; Janet L. Stein; Andre J. van Wijnen; Amjad Javed; Martin Montecino; Sayyed K. Zaidi; Daniel W. Young; Je-Yong Choi; Jitesh Pratap


Book ID
113418868
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
530 KB
Volume
45
Category
Article
ISSN
0065-2571

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## Abstract The osteoclast is a highly polarized multinucleated cell that resorbs bone. Using high resolution immunofluorescence microscopy, we demonstrated that all nuclei of an osteoclast are transcriptionally active. Each nucleus within the osteoclast contains punctately organized microenvironme