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Orally active PDE4 inhibitors with therapeutic potential

โœ Scribed by Hiroshi Ochiai; Tazumi Ohtani; Akiharu Ishida; Katuya Kishikawa; Takaaki Obata; Hisao Nakai; Masaaki Toda


Book ID
108073188
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
201 KB
Volume
14
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Orally Active Indol
โœ Christopher Hulme; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB

Orally Active Indole N-Oxide PDE4 Inhibitors. -An efficient synthesis to prepare a novel series of potent phosphodiesterase type IV inhibitors (VI) is described. Derivative (VIa) shows a good emetic and pharmacokinetic profile comparable to that of RP73401. -(HULME, CHRISTOPHER; ET