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OR.42. Human Heat Shock Protein 60 Induces Differentiation of Cd4+Cd3//Q T-Cells Into Foxp3+Cd4+Cd25//0 Regulatory T-Cells

✍ Scribed by Yvonne Vercoulen; Isme De Kleer; Sylvia Kamphuis; Huib de Jong; Mark Klein; Ger Rijkers; Willem van Eden; Salvatore Albani; Wietse Kuis; Berent Prakken

Book ID: 113539165
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 50 KB
Volume: 119
Category: Article
ISSN: 1090-2341
DOI: 10.1016/j.clim.2006.04.198

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a