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Total glucosides of paeony induces regulatory CD4+CD25+ T cells by increasing Foxp3 demethylation in lupus CD4+ T cells

✍ Scribed by Ming Zhao; Gong-ping Liang; Mei-ni Tang; Shuang-yan Luo; Jing Zhang; Wen-jing Cheng; Tak-Mao Chan; Qian-jin Lu

Book ID
113542083
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
773 KB
Volume
143
Category
Article
ISSN
1090-2341

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a