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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

✍ Scribed by Pandiyan, Pushpa; Zheng, Lixin; Ishihara, Satoru; Reed, Jennifer; Lenardo, Michael J

Book ID: 109923434
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 861 KB
Volume: 8
Category: Article
ISSN: 1529-2908
DOI: 10.1038/ni1536

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a