Inhibition of phosphoantigen-mediated γδ T-cell proliferation by CD4+ CD25+ FoxP3+ regulatory T cells
✍ Scribed by Volker Kunzmann; Brigitte Kimmel; Thomas Herrmann; Hermann Einsele; Martin Wilhelm
- Book ID
- 108782382
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 367 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0019-2805
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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d
## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a