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TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

✍ Scribed by Shuang Fu; Nan Zhang; Adam C. Yopp; Dongmei Chen; Minwei Mao; Dan Chen; Haojiang Zhang; Yaozhong Ding; Jonathan S. Bromberg

Book ID: 114803228
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 393 KB
Volume: 4
Category: Article
ISSN: 1600-6135
DOI: 10.1111/j.1600-6143.2004.00566.x

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a