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OR.121. Il-2 is Essential for TGF-β to Induce Peripheral Cd4+Cd25- T Cells to Become Cd4+Cd25+FoxP3-Expressing Regulatory T Cells


Book ID
113539310
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
62 KB
Volume
119
Category
Article
ISSN
1090-2341

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a