𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Optimization of the chiral resolution of baclofen by capillary electrophoresis using β-cyclodextrin as the chiral selector

✍ Scribed by Imran Ali; Hassan Y. Aboul-Enein

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
100 KB
Volume
24
Category
Article
ISSN
0173-0835

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The chiral resolution of baclofen was achieved by capillary electrophoresis using a fused‐silica capillary (60 cm×75 μm ID). The background electrolyte (BGE) was phosphate buffer (pH 7.0, 50 mM)‐acetonitrile (95:5 v/v) containing 10 mM β‐cyclodextrin. The applied voltage was 15 kV. The values of α and R~s~ were 1.06 and 1.00, respectively. The electrophoretic conditions were optimized varying the pH and the ionic strength of the BGE, concentrations of β‐cyclodextrin and acetonitrile and the applied voltage.

📜 SIMILAR VOLUMES

Resolution of enantiomeric N-oxides by c
Resolution of enantiomeric N-oxides by capillary electrophoresis using cyclodextrins as chiral selectors
✍ Mark R. Hadley; Sophie D. Gabriac; Andrew J. Hutt 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 2 views

The resolution of a series of rac-N-alkyl-N-methylaniline N-oxides and pargyline N-oxide (PNO) has been examined by capillary electrophoresis (CE) using both native and derivatised ␤-cyclodextrins (␤-CD) as chiral selectors. Resolution of the six analytes examined was achieved using either hydroxyet

Chiral separation of catechin by capilla
Chiral separation of catechin by capillary electrophoresis using mono-, di-, tri-succinyl-β-cyclodextrin as chiral selectors
✍ Hyunmyung Kim; Youngjin Choi; Jun Lim; Seung-R Paik; Seunho Jung 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 2 views

## Abstract The chiral separation of (±)‐catechin was investigated by capillary electrophoresis using characterized succinyl‐β‐cyclodextrins (Suc‐β‐CDs) with one to three degree of substitution values. The effects of nature and concentration of Suc‐β‐CDs and running buffer pH on the migration time

Chiral Separations of Enantiomeric Pharm
Chiral Separations of Enantiomeric Pharmaceuticals by Capillary Electrophoresis Using Sulphobutyl Ether β-Cyclodextrin as Isomer Selector
✍ Guang-hua Xie; David J. Skanchy; John F. Stobaugh 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

## Capillary electrophoresis has developed into an extremely useful technique for the separation of optical isomers. High efficiencies and the availability of many types of isomer selectors allowing rapid and inexpensive methods development make capillary electrophoresis (CE) an attractive alternat

Separation of basic drugs by capillary e
Separation of basic drugs by capillary electrophoresis using selectively modified cyclodextrins as chiral selectors
✍ Gerald Weseloh; Holger Bartsch; Wilfried A. König 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

## Abstract The influence of seven differently methylated β‐cyclodextrin derivatives and of pure β‐cyclodextrin (β‐CD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much mor