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Chiral separation of catechin by capillary electrophoresis using mono-, di-, tri-succinyl-β-cyclodextrin as chiral selectors

✍ Scribed by Hyunmyung Kim; Youngjin Choi; Jun Lim; Seung-R Paik; Seunho Jung

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
130 KB
Volume
21
Category
Article
ISSN
0899-0042

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✦ Synopsis

Abstract

The chiral separation of (±)‐catechin was investigated by capillary electrophoresis using characterized succinyl‐β‐cyclodextrins (Suc‐β‐CDs) with one to three degree of substitution values. The effects of nature and concentration of Suc‐β‐CDs and running buffer pH on the migration time and resolution of (±)‐catechin are discussed. All three kinds of Suc‐β‐CDs show a clear baseline separation of (±)‐catechin in capillary electrophoresis. Mono‐Suc‐β‐CD effectively separated (±)‐catechin, and additional substituted CDs (di‐ and tri‐Suc‐β‐CD) were capable of chiral separation at a broad pH range. The optimum running conditions were found to be 100 mM borate buffer (pH 9.8) containing 5 mM mono‐Suc‐β‐CD with no methanol organic modifier. Chirality, 2009. © 2009 Wiley‐Liss, Inc.

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