## Abstract The chiral resolution of baclofen was achieved by capillary electrophoresis using a fused‐silica capillary (60 cm×75 μm ID). The background electrolyte (BGE) was phosphate buffer (pH 7.0, 50 mM)‐acetonitrile (95:5 v/v) containing 10 mM β‐cyclodextrin. The applied voltage was 15 kV. The
Capillary electrophoretic resolution of chiral aryl alkyl and aryl benzyl sulphoxides using sulphated β-cyclodextrins as chiral selectors
✍ Scribed by Mark R. Hadley; Marie Decrette; Gaelle Guilloré; Carlo Rosini; Maria I. Donnoli; Stefano Superchi; Andrew J. Hutt
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 152 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1615-9306
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The resolution of a series of rac-N-alkyl-N-methylaniline N-oxides and pargyline N-oxide (PNO) has been examined by capillary electrophoresis (CE) using both native and derivatised -cyclodextrins (-CD) as chiral selectors. Resolution of the six analytes examined was achieved using either hydroxyet
## Abstract High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged β‐cyclodextrin derivatives. The interaction of the analytes with the ani