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Optimal two-stage designs for clinical trials with binary response

โœ Scribed by Peter F. Thall; Richard Simon; Susan S. Ellenberg; Shrager


Book ID
119143674
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
78 KB
Volume
9
Category
Article
ISSN
0197-2456

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The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at