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A two-stage design for randomized trials with binary outcomes

✍ Scribed by Sam Wieand; Terry Therneau


Book ID
119143441
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
500 KB
Volume
8
Category
Article
ISSN
0197-2456

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## Abstract A two‐stage design is proposed to choose among several experimental treatments and a standard treatment in clinical trials. The first stage employs a selection procedure to select the best treatment, provided it is better than the standard. The second stage tests the hypothesis between