✦ LIBER ✦

A Two-stage Design for Comparing Clinical Trials

✍ Scribed by Pinyuen Chen; Lifang Hsu

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 321 KB
Volume: 34
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710340104

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A two‐stage design is proposed to choose among several experimental treatments and a standard treatment in clinical trials. The first stage employs a selection procedure to select the best treatment, provided it is better than the standard. The second stage tests the hypothesis between the best treatment selected at the first stage (if any) and the standard treatment. All the treatments are assumed to follow normal distributions and the best treatment is the one with the largest population mean. The level and the power are defined and they are used to set up equations to solve unknown first stage sample size, second stage sample size, and procedure parameters. The optimal design is the one that gives the smallest average sample size. Numerical results are presented to illustrate the improvement of one design as compared to existing one stage design.

📜 SIMILAR VOLUMES

Optimal three-stage designs for phase II

Optimal three-stage designs for phase II cancer clinical trials

✍ T. Timothy Chen 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 2 views

The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at

Clinical trial design for antiepileptic

Clinical trial design for antiepileptic drugs

✍ James J. Cereghino 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

In this issue of the Annals, Sachdeo and colleagues report on the efficacy of felbamate for partial onset seizures. They utilized a vahd active treatment control design, which was designed to show and did show a difference in efficacy 11). These results may be consid-

Mid-trial design reviews for sequential

Mid-trial design reviews for sequential clinical trials

✍ John Whitehead; Anne Whitehead; Susan Todd; Kim Bolland; M. Roshini Sooriyarachc 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 1 views

Another look at two phase I clinical tri

Another look at two phase I clinical trial designs

✍ John O'Quigley 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 76 KB 👁 1 views

This note is a response to a recent paper by Korn et al. in which two phase I trial designs were compared, the designs in question being the standard design and the CRM design. The authors concluded that: (i) CRM designs will take longer to complete than standard designs; and (ii) CRM designs are le

A second clinical trial to compare two m

A second clinical trial to compare two methods for preoperative preparation of the large bowel

✍ R. A. Sellwood; J. Ian Burn; Pamela M. Waterworth; R. B. Welbourn 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 316 KB

Likelihood inference for a two-stage des

Likelihood inference for a two-stage design with treatment selection

✍ Ionut Bebu; George Luta; Vladimir Dragalin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB

## Abstract A conditional likelihood‐based approach is proposed to construct confidence intervals for the parameters of interest in a two‐stage design with treatment selection after the first stage. Both a Wald confidence interval and a confidence interval based on inverting the likelihood ratio te