Optimal Control of Drug Administration in Cancer Chemotherapy
β Scribed by George W. Swan
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 112 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1522-9602
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Analytical gradients of all constraints are constructed and the problem solved numerically. The optimal treatment is low intensity therapy followed by high intensity therapy.
Time-dependent toxicity of 3 anti-cancer drugs was demonstrated in BALB/c mice. Cisplatinum, adriamycin and cyclophosphamide were injected at 4 different circadian stages, either together (combined injection) or separately, to different groups of mice. Toxicity was evaluated by body-weight changes,
Cancer chemotherapy with application of one drug is studied. The negative and inhibiting e ect of the tumor on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumor burden at the end of a ΓΏxed period of therapy while maintaining the