𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Optimal Control of Drug Administration in Cancer Chemotherapy

✍ Scribed by George W. Swan


Publisher
Springer
Year
1995
Tongue
English
Weight
112 KB
Volume
57
Category
Article
ISSN
1522-9602

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Optimal control drug scheduling of cance
✍ R.B. Martin πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 892 KB

Analytical gradients of all constraints are constructed and the problem solved numerically. The optimal treatment is low intensity therapy followed by high intensity therapy.

Time-dependent toxicity of drugs used in
✍ L. Peleg; I. E. Ashkenazi; R. Carlebach; S. Chaitchik πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 376 KB

Time-dependent toxicity of 3 anti-cancer drugs was demonstrated in BALB/c mice. Cisplatinum, adriamycin and cyclophosphamide were injected at 4 different circadian stages, either together (combined injection) or separately, to different groups of mice. Toxicity was evaluated by body-weight changes,

Application of optimal control theory to
✍ Alexey S. Matveev; Andrey V. Savkin πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 145 KB

Cancer chemotherapy with application of one drug is studied. The negative and inhibiting e ect of the tumor on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumor burden at the end of a ΓΏxed period of therapy while maintaining the