𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Optimal control drug scheduling of cancer chemotherapy

✍ Scribed by R.B. Martin

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
892 KB
Volume
28
Category
Article
ISSN
0005-1098

No coin nor oath required. For personal study only.

✦ Synopsis

Analytical gradients of all constraints are constructed and the problem solved numerically. The optimal treatment is low intensity therapy followed by high intensity therapy.

πŸ“œ SIMILAR VOLUMES

Application of optimal control theory to
Application of optimal control theory to analysis of cancer chemotherapy regimens
✍ Alexey S. Matveev; Andrey V. Savkin πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 145 KB

Cancer chemotherapy with application of one drug is studied. The negative and inhibiting e ect of the tumor on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumor burden at the end of a ΓΏxed period of therapy while maintaining the

State-constrained optimal control applie
State-constrained optimal control applied to cell-cycle-specific cancer chemotherapy
✍ M. Alamir; S. Chareyron πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 675 KB

## Abstract In this paper, the optimal drug injection problem arising in cancer treatment by cell‐cycle‐specific chemotherapy is investigated. The optimal control problem is state constrained in which the stage cost reflects the concern of maximal drug injection, while the state constraint imposes