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Application of optimal control theory to analysis of cancer chemotherapy regimens

✍ Scribed by Alexey S. Matveev; Andrey V. Savkin

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
145 KB
Volume
46
Category
Article
ISSN
0167-6911

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✦ Synopsis

Cancer chemotherapy with application of one drug is studied. The negative and inhibiting e ect of the tumor on normal cells is taken into account. Under certain assumptions, we determine the optimal regimen that minimizes the tumor burden at the end of a ΓΏxed period of therapy while maintaining the normal cell population above a prescribed level.

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