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Time-dependent toxicity of drugs used in cancer chemotherapy: Separate and combined administration

✍ Scribed by L. Peleg; I. E. Ashkenazi; R. Carlebach; S. Chaitchik

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
376 KB
Volume
44
Category
Article
ISSN
0020-7136

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✦ Synopsis

Time-dependent toxicity of 3 anti-cancer drugs was demonstrated in BALB/c mice. Cisplatinum, adriamycin and cyclophosphamide were injected at 4 different circadian stages, either together (combined injection) or separately, to different groups of mice. Toxicity was evaluated by body-weight changes, mortality and white blood cell counts. Maximal body-weight loss was caused by the administration of either Cisplatinum or the combination of all 3 drugs at 15.00 hr and 2 I .OO hr, i.e., 9 and I 5 hr after fight on (HALO). Only moderate body weight loss was induced when adriamycin was injected at 09.00 hr or at 2 I .OO hr (3 and I 5 HALO). In contrast

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