The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at
โฆ LIBER โฆ
Optimal and minimax three-stage designs for phase II oncology clinical trials
โ Scribed by Kun Chen; Michael Shan
- Book ID
- 116350665
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 162 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1551-7144
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In the conduct of a phase II cancer clinical trial, patients usually enter in two stages. If the response rate from the first stage is low, then the study terminates. Within various two-stage designs, Simon proposed the optimal and minimax criteria. In the co-operative group setting, practical consi
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