Opposing effects of HLA–DRB1*13 alleles on the risk of developing anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis
✍ Scribed by Emeli Lundström; Henrik Källberg; Marina Smolnikova; Bo Ding; Johan Rönnelid; Lars Alfredsson; Lars Klareskog; Leonid Padyukov
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 69 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To identify additional variants in the major histocompatibility complex (MHC) region that independently contribute to risk in 2 disease subsets of rheumatoid arthritis (RA) defined according to the presence or absence of antibodies to citrullinated protein antigens (ACPAs)
## Abstract ## Objective To examine the association between HLA–DRB1 alleles and the production of anti–cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF) autoantibodies in patients with rheumatoid arthritis (RA). ## Methods We studied 1,723 Caucasian RA patients enrolled in the