Contribution of a haplotype in the HLA region to anti–cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA–DRB1
✍ Scribed by Yukinori Okada; Ryo Yamada; Akari Suzuki; Yuta Kochi; Kenichi Shimane; Keiko Myouzen; Michiaki Kubo; Yusuke Nakamura; Kazuhiko Yamamoto
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 96 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To examine the association between HLA–DRB1 alleles and the production of anti–cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF) autoantibodies in patients with rheumatoid arthritis (RA). ## Methods We studied 1,723 Caucasian RA patients enrolled in the
## Abstract ## Objective The shared epitope (SE)–containing HLA–DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti–cyclic citrullinated