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Gene–environment interaction between the DRB1 shared epitope and smoking in the risk of anti–citrullinated protein antibody–positive rheumatoid arthritis: All alleles are important

✍ Scribed by Emeli Lundström; Henrik Källberg; Lars Alfredsson; Lars Klareskog; Leonid Padyukov


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
74 KB
Volume
60
Category
Article
ISSN
0004-3591

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The HLA–DRB1 shared epitope alleles are
✍ Annette H. M. van der Helm-van Mil; Kirsten N. Verpoort; Ferdinand C. Breedveld; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB 👁 1 views

## Abstract ## Objective The shared epitope (SE)–containing HLA–DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti–cyclic citrullinated