On-line solid phase synthesis of oligonucleotide-peptide hybrids using silica supports
✍ Scribed by Jean-Christophe Truffert; Olivier Lorthioir; Ulysse Asseline; Nguyen T. Thuong; André Brack
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 349 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected or-amino aldehyde with MBHA-supported Wittig ou Winig-Horner reagent yielded resin-linked ~-~-unsaturated 8-amino derivative. After elongation of the peptide chain, ozonolysis produced fair
Very fast (4 sec) attachment of nucleosides to CPG supports, via succinyl or QDA linkers, is possible with either uronium (HBTU, HATU, HBPyU, HBPipU) or phospbonium (BOP, PyBOP ®, Py-BroP, BroP) coupling reagents and automated derivatization of CPG and polystyrene supports just prior to oligonucleot