Iaobufalinl 1 was synthesized from testosterone. A novel use of a-furans as masking groups of a carboxylic acid is also reported.
On cardioactive steroids. XII. The synthesis of (natural) bufalin and α′-isobufalin
✍ Scribed by Karel Wiesner; Thomas Y. R. Tsai; Alina Sen; Ravindra Kumar; Masayoshi Tsubuki
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- German
- Weight
- 533 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
An efficient and simple synthesis of bufalin (1) via furan‐containing intermediates is described. The same method was also used for the synthesis of α‐isobufalin (2) which was prepared with equal simplicity, but in lower yield.
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