✦ LIBER ✦
On cardioactive steroids. Communication XV. A stereoselective synthesis of (21R)-21-methyldigitoxigenin, a fully active cardenolide with a wide margin of safety: A contribution to the topology of the Digitalis receptors
✍ Scribed by Karel Wiesner; Thomas Y. R. Tsai; Ravindra Kumar; Harihran Sivaramakrishnan
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- German
- Weight
- 515 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Two efficient preparations of the title compound, one from common C~19~‐steroids, the other frm digitoxigenin, are described. The less active minor epimer (21__S__)‐methyldigitoxigenin was also obtained and characterized. The positive inotropic effects and margins of safety of the two C(21)‐epimers (tested as glucosides) are discussed in terms of the topological properties of the Digitalis receptors.