## Abstract An efficient and simple synthesis of bufalin **(1)** __via__ furan‐containing intermediates is described. The same method was also used for the synthesis of α‐isobufalin **(2)** which was prepared with equal simplicity, but in lower yield.
On Cardioactive Steroids. VIII. The Synthesis of Bufalin and Resibufogenin Isomers
✍ Scribed by Karel Wiesner; Thomas Y. R. Tsai; Franz J. Jäggi; Connie S. J. Tsai; Glenna D. Gray
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- German
- Weight
- 781 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
α‐IsobufalinSystematic names are given at the titles of the Exper. Part.
(1) and β‐isoresibufogenin (3) have been synthesized from testosterone by a method which features a novel oxidative furan to pyrone transformation.
📜 SIMILAR VOLUMES
Iaobufalinl 1 was synthesized from testosterone. A novel use of a-furans as masking groups of a carboxylic acid is also reported.
## Abstract Two efficient preparations of the title compound, one from common C~19~‐steroids, the other frm digitoxigenin, are described. The less active minor epimer (21__S__)‐methyldigitoxigenin was also obtained and characterized. The positive inotropic effects and margins of safety of the two C