𝔖 Bobbio Scriptorium
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On Cardioactive Steroids. VIII. The Synthesis of Bufalin and Resibufogenin Isomers

✍ Scribed by Karel Wiesner; Thomas Y. R. Tsai; Franz J. Jäggi; Connie S. J. Tsai; Glenna D. Gray


Publisher
John Wiley and Sons
Year
1982
Tongue
German
Weight
781 KB
Volume
65
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

α‐IsobufalinSystematic names are given at the titles of the Exper. Part.

(1) and β‐isoresibufogenin (3) have been synthesized from testosterone by a method which features a novel oxidative furan to pyrone transformation.


📜 SIMILAR VOLUMES


On cardioactive steroids. XII. The synth
✍ Karel Wiesner; Thomas Y. R. Tsai; Alina Sen; Ravindra Kumar; Masayoshi Tsubuki 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 German ⚖ 533 KB

## Abstract An efficient and simple synthesis of bufalin **(1)** __via__ furan‐containing intermediates is described. The same method was also used for the synthesis of α‐isobufalin **(2)** which was prepared with equal simplicity, but in lower yield.

On cardioactive steroids: The synthesis
✍ Sergio Lociuro; Thomas Y.R. Tsai; Karel Wiesner 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 422 KB

Iaobufalinl 1 was synthesized from testosterone. A novel use of a-furans as masking groups of a carboxylic acid is also reported.

On cardioactive steroids. Communication
✍ Karel Wiesner; Thomas Y. R. Tsai; Ravindra Kumar; Harihran Sivaramakrishnan 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 German ⚖ 515 KB

## Abstract Two efficient preparations of the title compound, one from common C~19~‐steroids, the other frm digitoxigenin, are described. The less active minor epimer (21__S__)‐methyldigitoxigenin was also obtained and characterized. The positive inotropic effects and margins of safety of the two C