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Isolation and synthesis of the first natural 6-hydroximino 4-en-3-one- steroids from the sponges Cinachyrella spp

✍ Scribed by Jaime Rodríguez; Lucia Nuñez; Solange Peixinho; Carlos Jiménez

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 206 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00163-9

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✦ Synopsis

Two new 6-hydroximino-4-en-3-one steroids: (24R, 6E)-24-ethylcholest-6-hydroximino-4en-3-one (1) and (6E) cholest-6-hydroximino-4-en-3-one (2), accompanied by the known cholest-4-en-3-one wexe isolated from a mixttwe of two morphospecies of the sponge Cinachyrella (C. alloclada and C. apion). Use of spectroscopic methods (NMR and MS) was key to establish their structures which were eonfn'med by synthesis. Described in this report are the fwst hydroximino steroids derived from a natural source.

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