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O6-methylguanine-DNA methyltransferase deficiency in developing brain: Implications for brain tumorigenesis

✍ Scribed by Michael S. Bobola; A. Blank; Mitchel S. Berger; John R. Silber


Book ID
113567847
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
449 KB
Volume
6
Category
Article
ISSN
1568-7864

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## Abstract __O__^6^‐methylguanine‐DNA methyltransferase (__MGMT__) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within __MGMT__ promoter leads to loss of its protein expression, and i