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Nucleotides. Part XXXVIII.. Syntheses and characterization of phosphorothioate analogues of (2′–5′) adenylate dimer and trimer and their 5′-O-monophosphates

✍ Scribed by Ramamurthy Charubala; Wolfgang Pfleiderer

Publisher: John Wiley and Sons
Year: 1992
Tongue: German
Weight: 551 KB
Volume: 75
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19920750206

No coin nor oath required. For personal study only.

✦ Synopsis

Dedicated to Prof. Dr. Wilhelm Fleischhacker on the occasion of his 60th birthday (8.X1.91) ~ ~~

The chemical syntheses of the phosphorothioate of (2'-5')adenylate dimer (see 6a, 6b) and trimer (see 1 la, 1 lb, 12a, 12b) as well as of their 5'-monophosphates (see 15a, 15b, 16a, 16b) using the phosphoramidite method are described. The resulting diastereoisomer mixtures were separated into the pure components by chromatographical means. All synthetic intermediates were characterized by TLC, elemental analysis, and UV and 'H-NMR spectra.

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