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Nucleotides Part XL. Synthesis and Characterization of Modified 2′–5′ Adenylate Trimers–Potential Antiviral Agents

✍ Scribed by Helga Schirmeister; Wolfgang Pfleiderer

Publisher: John Wiley and Sons
Year: 1994
Tongue: German
Weight: 1000 KB
Volume: 77
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19940770104

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✦ Synopsis

Abstract

2′–5′ Adenylate trimers 41–44 carrying the (tert‐butyl)dimethylsilyl (tbds) group at the 3′‐OH position of various sugar moieties were synthesized via the phosphoramidite method. The use of the (tert‐butyloxy)carbonyl (boc) and 2‐(4‐nitrophenyl)ethylsulfonyl (npes) groups for 2′‐OH protection in neighbourhood to the 3′‐O‐tbds residue was compared during the synthesis of the target trimers. For other functional positions, the use of the 2‐(4‐nitrophenyl)ethyl (npe) and 2‐(4‐nitrophenyl)ethoxycarbonyl (npeoc) blocking groups were favoured.

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