✦ LIBER ✦

Nucleotides. Part XXXVI. Syntheses and biological characterization of phosphorothioate analogues of (3′–5′)adenylate trimer

✍ Scribed by Ramamurthy Chambala; Robert W. Sobol; Ning Kon; Robert J. Suhadolnik; Wolfgang Pfleiderer

Publisher: John Wiley and Sons
Year: 1991
Tongue: German
Weight: 448 KB
Volume: 74
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19910740420

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The four protected diastereoisomcrs 7a/7b and 8a/8b P‐thioadenylyl‐(3′–5′)‐P‐thioadenylyI‐(3′–5′)‐adenosine were synthesized, separated, and deblocked to the free oligonucleotides (Scheme). Biochemical characterization of these (3′–5′)phosphorothioate analogues of adenyiate trimer indicate that these compounds, and the corresponding 5′‐monophosphates, neither bind to nor activate RNase L, and are considered to be valuable control compounds in screening experiments.

📜 SIMILAR VOLUMES

Nucleotides. Part XXXVIII.. Syntheses an

Nucleotides. Part XXXVIII.. Syntheses and characterization of phosphorothioate analogues of (2′–5′) adenylate dimer and trimer and their 5′-O-monophosphates

✍ Ramamurthy Charubala; Wolfgang Pfleiderer 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 German ⚖ 551 KB

Dedicated to Prof. Dr. Wilhelm Fleischhacker on the occasion of his 60th birthday (8.X1.91) ~ ~~ The chemical syntheses of the phosphorothioate of (2'-5')adenylate dimer (see 6a, 6b) and trimer (see 1 la, 1 lb, 12a, 12b) as well as of their 5'-monophosphates (see 15a, 15b, 16a, 16b) using the phosp

Nucleotides Part XL. Synthesis and Chara

Nucleotides Part XL. Synthesis and Characterization of Modified 2′–5′ Adenylate Trimers–Potential Antiviral Agents

✍ Helga Schirmeister; Wolfgang Pfleiderer 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 German ⚖ 1000 KB

## Abstract 2′–5′ Adenylate trimers 41–44 carrying the (__tert__‐butyl)dimethylsilyl (tbds) group at the 3′‐OH position of various sugar moieties were synthesized __via__ the phosphoramidite method. The use of the (__tert__‐butyloxy)carbonyl (boc) and 2‐(4‐nitrophenyl)ethylsulfonyl (npes) groups fo

ChemInform Abstract: Nucleotides. Part 5

ChemInform Abstract: Nucleotides. Part 59. Synthesis, Characterization, and Biological Activities of New Potential Antiviral Agents. (2′-5′) Adenylate Trimer Analogues Containing 3′-Deoxy-3′-(hexadecanoylamino)adenosine at the 2′-Terminus.

✍ Helga Schirmeister-Tichy; Kathryn T. Iacono; Nicholas F. Muto; Joseph W. Homan; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Nucleotides, Part LIX , Synthesis, Chara

Nucleotides, Part LIX , Synthesis, Characterization, and Biological Activities of New Potential Antiviral Agents: (2′ – 5′)Adenylate Trimer Analogs Containing 3′-Deoxy-3′-(hexadecanoylamino)adenosine at the 2′-Terminus

✍ Helga Schirmeister-Tichy; Kathryn T. Iacono; Nicholas F. Muto; Joseph W. Homan; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 German ⚖ 242 KB 👁 2 views

ChemInform Abstract: Nucleotides. Part 5

ChemInform Abstract: Nucleotides. Part 51. Synthesis and Biological Activities of (2′—5′)Adenylate Trimer Conjugates with 2′-Terminal 3′-O-(ω-Hydroxyalkyl) and 3′-O-(ω-Carboxyalkyl) Spacers.

✍ C. HOERNDLER; R. J. SUHADOLNIK; N. F. MUTO; HENDERSON E. E. HENDERSON E. E.; M.- 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Nucleotides. Part XLVII. Synthesis of 3′

Nucleotides. Part XLVII. Synthesis of 3′-Deoxyadenylyl-(2′–5′)-3′-deoxyadenylyl-(2′–5′)-3′-O-(2-hydroxyethyl)adenosine and 3′-Deoxyadenylyl-(2′–5′)-3′-deoxyadenylyl-(2′–5′)-3′-O-{2-[(cholest-5-en-3β-yloxy)carbonyloxy]ethyl}adenosine: A New Type of (2′–5′)Adenylate Trimer Conjugate

✍ Cornelia Hörndler; Wolfgang Pfleiderer 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 688 KB