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Nuclear microenvironments and cancer

✍ Scribed by Gary S. Stein; James R. Davie; J. Randy Knowlton; Sayyed K. Zaidi

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
66 KB
Volume
104
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Nucleic acids and regulatory proteins are architecturally organized in nuclear microenvironments. The compartmentalization of regulatory machinery for gene expression, replication and repair, is obligatory for fidelity of biological control. Perturbations in the organization, assembly and integration of regulatory machinery have been functionally linked to the onset and progression of tumorigenesis. The combined application of cellular, molecular, biochemical and in vivo genetic approaches, together with structural biology, genomics, proteomics and bioinformatics, will likely lead to new approaches in cancer diagnostics and therapy. J. Cell. Biochem. 104: 1949–1952, 2008. Β© 2008 Wiley‐Liss, Inc.

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