𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pancreatic cancer microenvironment

✍ Scribed by Jörg Kleeff; Philipp Beckhove; Irene Esposito; Stephan Herzig; Peter E. Huber; J. Matthias Löhr; Helmut Friess

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
539 KB
Volume
121
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Pancreatic ductal adenocarcinoma remains an extremely aggressive malignancy that is virtually therapy‐resistant and has therefore one of the worst prognoses of all human cancers. The focus of research, which had been placed mostly on genetic and epigenetic alterations of the cancer cells themselves, has shifted gradually towards the microenvironment. The cancer microenvironment consists of various components, including fibroblasts, endothelial cells, immune cells, and endocrine cells, that interact with each other and the cancer cells in a complex fashion. This interplay has implications for pancreatic cancer cell growth, migration and invasion, angiogenesis, and immunological recognition of cancer cells. Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells to improve the outcome of this deadly disease. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Nuclear microenvironments and cancer
Nuclear microenvironments and cancer
✍ Gary S. Stein; James R. Davie; J. Randy Knowlton; Sayyed K. Zaidi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 66 KB

## Abstract Nucleic acids and regulatory proteins are architecturally organized in nuclear microenvironments. The compartmentalization of regulatory machinery for gene expression, replication and repair, is obligatory for fidelity of biological control. Perturbations in the organization, assembly a

Familial pancreatic cancer
Familial pancreatic cancer
✍ D. K. Bartsch 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 51 KB 👁 1 views
Brachytherapy and pancreatic cancer
Brachytherapy and pancreatic cancer
✍ William R. Bodner; Basil S. Hilaris 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB 👁 2 views

Advances in diagnostic and therapeutic technology have not appreciably changed the outlook of patients with pancreatic cancer. While those patients presenting with localized resectable disease have the best prognosis, local control and intra-abdominal metastases remain significant obstacles to survi

Epidemiology of pancreatic cancer
Epidemiology of pancreatic cancer
✍ Suketami Tominaga; Tetsuo Kuroishi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB 👁 2 views

This paper reviews recent trends in pancreatic cancer worldwide. The mortality rate for pancreatic cancer is high in Denmark, Sweden, Finland, Ireland, and some other European countries, but it is low in Asian and southern European countries. A positive correlation was observed between geographical