𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nuclear analogs of β-lactam antibiotics. V. Synthesis of a benzo-fused carbocyclic β-lactam.

✍ Scribed by Joseph Finkelstein; Kenneth G. Holden; Carl D. Perchonock

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
197 KB
Volume
19
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Because of their central role in the treatment of bacterial infection, the 8-lactam antibiotics have received a tremendous amount of attention since their discovery. While the majority of chemical effort has been devoted to the preparation of semi-synthetic penicillins and cephalosporins, recent work has increasingly focused on total synthesis, through which may be obtained novel compounds not readily derived from natural sources. ls2 One of the significant results from these efforts is the observation that biological activity is retained when the sulfur atom of cephalosporins is replaced by carbon.' As part of our continuing work in this

📜 SIMILAR VOLUMES

Nuclear analogs of β-lactam antibiotics.
Nuclear analogs of β-lactam antibiotics. III. Derivatives incorporating a hydrazine moiety.
✍ Joseph Finkelstein; Kenneth G. Holden; Rayvon Sneed; Carl D. Perchonock 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 214 KB

8-lactam antibiotica today play a key role in bacterial chemotherapy. Because of their high potency, wide spectrum of activity, and low masnnalian toxicity, they constitute almost ideal agents for the treatment of bacterial infection. Furthermore, they are quite interesting from a chemical point of