𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nuclear analogs of β-lactam antibiotics. III. Derivatives incorporating a hydrazine moiety.

✍ Scribed by Joseph Finkelstein; Kenneth G. Holden; Rayvon Sneed; Carl D. Perchonock

Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
214 KB
Volume
18
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

8-lactam antibiotica today play a key role in bacterial chemotherapy. Because of their high potency, wide spectrum of activity, and low masnnalian toxicity, they constitute almost ideal agents for the treatment of bacterial infection. Furthermore, they are quite interesting from a chemical point of view. Concentrating a high degree of functionality in a rather small molecular volume, they present a significant challenge to the synthetic organic chemist. By and large, most of the work to date on the 8-lactam antibiotics has dealt with structural modifications of naturally derived penicillins and cephalosporins.

Recently, however, an increasing number of research groups have turned their attention to total synthesis efforts,L which offer the potential of producing novel ring systems with improved biological properties. In this communication, we report our own results on the synthesis of some bi-and tricyclic 8-lactam nuclear analogs (Q-.ll> that incorporate a hydraxine moiety.

📜 SIMILAR VOLUMES

Nuclear analogs of β-lactam antibiotics.
Nuclear analogs of β-lactam antibiotics. V. Synthesis of a benzo-fused carbocyclic β-lactam.
✍ Joseph Finkelstein; Kenneth G. Holden; Carl D. Perchonock 📂 Article 📅 1978 🏛 Elsevier Science 🌐 French ⚖ 197 KB

Because of their central role in the treatment of bacterial infection, the 8-lactam antibiotics have received a tremendous amount of attention since their discovery. While the majority of chemical effort has been devoted to the preparation of semi-synthetic penicillins and cephalosporins, recent wor