Enzymatic synthesis of β-lactam antibiotics: A thermodynamic background
✍ Scribed by Vytas K. Švedas; Alexei L. Margolin; Ilya V. Berezin
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 640 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0141-0229
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Cycloaddition of nitrone (2) to a-chloroacrylonitrile followed by hydrolysis afforded the isoxazolidinone (I) as a single diastereomer.
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Because of their central role in the treatment of bacterial infection, the 8-lactam antibiotics have received a tremendous amount of attention since their discovery. While the majority of chemical effort has been devoted to the preparation of semi-synthetic penicillins and cephalosporins, recent wor
a-Thioformamido-diethylphosphonoacetates (I) have been found to condense with lcbloro-2-propanones in the presence of base to give 6H-1,3-thiazine-4-carboxylates (II).