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Total synthesis of β-lactam antibiotics II. (±)-cephalothin

✍ Scribed by Ronald W. Ratcliffe; B.G. Christensen

Publisher: Elsevier Science
Year: 1973
Tongue: French
Weight: 215 KB
Volume: 14
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)87299-3

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✦ Synopsis

a-Thioformamido-diethylphosphonoacetates (I) have been found to condense with lcbloro-2-propanones in the presence of base to give 6H-1,3-thiazine-4-carboxylates (II).

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