Novel Synthesis and Antitumor Evaluation of Polyfunctionally Substituted Heterocyclic Compounds Derived from 2-Cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide
β Scribed by Shams, Hoda Z.; Mohareb, Rafat M.; Helal, Maher H.; Mahmoud, Amira E.
- Book ID
- 118205293
- Publisher
- Molecular Diversity Preservation International
- Year
- 2010
- Tongue
- English
- Weight
- 219 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1420-3049
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## Abstract The reaction of 2βaminoβ3βcyanoβ4,5,6,7βtetrahydrobenzo[b]thiophene (**1**) with diethyl malonate (**2**) gave two products: **3** and **4**. The reactivity of **3** toward a variety of chemical reagents was studied to give azoles, azines, and their fused derivatives. Β© 2001 John Wiley
## Abstract The reaction of 2βaminoβ3βcyanoβ4,5,6,7βtetrahydrobenzo[b]thiophene **1** with ethyl acetoacetate **2** gave compound **3**. The reactivity of the latter product toward a variety of chemical reagents was studied to give fused thiophene derivatives of potential pharmaceutical interest. Β©