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The reaction of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]-thiophene with diethyl malonate: synthesis of coumarin, pyridine, and thiazole derivatives

✍ Scribed by Rafat M. Mohareb; Fatma A. El-Omran; Jonathan Z. Ho

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
114 KB
Volume
12
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The reaction of 2‐amino‐3‐cyano‐4,5,6,7‐tetrahydrobenzo[b]thiophene (1) with diethyl malonate (2) gave two products: 3 and 4. The reactivity of 3 toward a variety of chemical reagents was studied to give azoles, azines, and their fused derivatives. © 2001 John Wiley & Sons, Inc. Heteroatom Chem 12:168–175, 2001

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## Abstract 2‐Amino‐3‐cyano‐4,5,6,7‐tetrahydrobenzo[__b__]thiophene **1a** or 2‐amino‐3‐cyano‐4,7‐di‐ phenyl‐5‐methyl‐4__H__‐pyrano[2,3‐__c__]pyrazole **2a** reacted with phenylisocyanate in dry pyridine to give 2‐(3‐phenylureido)‐3‐cyanobenzo[b]thiophene **1b** or 2‐disubstituted amino‐3‐cyanopyra