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Reaction of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophene with ethyl acetoacetate: Novel syntheses of pyridines, pyrazoles, and their fused derivatives

✍ Scribed by Rafat M. Mohareb; Mona H. Mohamed

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
223 KB
Volume
12
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The reaction of 2‐amino‐3‐cyano‐4,5,6,7‐tetrahydrobenzo[b]thiophene 1 with ethyl acetoacetate 2 gave compound 3. The reactivity of the latter product toward a variety of chemical reagents was studied to give fused thiophene derivatives of potential pharmaceutical interest. © 2001 John Wiley & Sons, Inc. Heteroatom Chem 12:518–527, 2001

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