The title compounds, (+)-14-fluoro-4-demethoxy-and (+)-14-fluorodaunorubicin, were synthesized from (-)-7-deoxy-4-demethoxy-and (-)-7-deoxydaunomycinone, respectively, by featuring the novel fluorination reaction in which tetrabuthylammonium fluoride is employed in the presence of a half equiv of p-
Novel synthesis and antitumor activity of 14,14-difluoro-4-demethoxydaunorubicin
✍ Scribed by Fuyuhiko Matsuda; Teruyo Matsumoto; Masako Ohsaki; Shiro Terashima
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 325 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The title anthracycline was synthesized via (-)-14.14-difluoro-4-demethoxy-7-
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