Novel somatic mutations in the VHL gene in Swedish archived sporadic renal cell carcinomas
โ Scribed by Ke Yang; Per Lindblad; Lars Egevad; Kari Hemminki
- Book ID
- 117469398
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 209 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0304-3835
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๐ SIMILAR VOLUMES
## Abstract To delineate more precisely the somatic von HippelโLindau disease (VHL) gene alteration as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 sporadic renal cell carcinomas (RCCs) for somatic __VHL__ gene alterations by DNAโSSCP followed by sequen
## Communicated by Albert de la Chapelle To investigate the nature of somatic von Hippel-Lindau (VHL) mutations, we analyzed 173 primary sporadic human renal cell carcinomas for mutations of the VHL tumor suppressor gene, using polymerase chain reaction (PCR) and single-strand conformational polym