Determination of vhl Gene Mutations in Sporadic Renal Cell Carcinoma
✍ Scribed by José Miguel Giménez-Bachs; Antonio S. Salinas-Sánchez; Francisco Sánchez-Sánchez; Juan G. Lorenzo-Romero; María José Donate-Moreno; Héctor Pastor-Navarro; Dolores C. García-Olmo; Julio Escribano-Martínez; Julio A. Virseda-Rodríguez
- Book ID
- 113609100
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 227 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0302-2838
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## Abstract To delineate more precisely the somatic von Hippel‐Lindau disease (VHL) gene alteration as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 sporadic renal cell carcinomas (RCCs) for somatic __VHL__ gene alterations by DNA‐SSCP followed by sequen
## Communicated by Albert de la Chapelle To investigate the nature of somatic von Hippel-Lindau (VHL) mutations, we analyzed 173 primary sporadic human renal cell carcinomas for mutations of the VHL tumor suppressor gene, using polymerase chain reaction (PCR) and single-strand conformational polym