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VHL gene alterations in renal cell carcinoma patients: novel hotspot or founder mutations and linkage disequilibrium

✍ Scribed by Ma, Xin; Yang, Ke; Lindblad, Per; Egevad, Lars; Hemminki, Kari


Book ID
110065940
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
177 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Communicated by Albert de la Chapelle To investigate the nature of somatic von Hippel-Lindau (VHL) mutations, we analyzed 173 primary sporadic human renal cell carcinomas for mutations of the VHL tumor suppressor gene, using polymerase chain reaction (PCR) and single-strand conformational polym