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Novel Nonsteroidal Antiinflammatory Drugs Possessing a Nitric Oxide Donor Diazen-1-ium-1,2-diolate Moiety: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies

✍ Scribed by Velázquez, Carlos; Praveen Rao, P. N.; Knaus, Edward E.

Book ID
120395124
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
345 KB
Volume
48
Category
Article
ISSN
0022-2623

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Celecoxib prodrugs possessing a diazen-1
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies
✍ Khaled R.A. Abdellatif; Morshed A. Chowdhury; Carlos A. Velázquez; Zhangjian Hua 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 284 KB

A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2diolato ammonium salt, and its O 2 -methyl and O 2 -acetoxyethyl derivatives, nitric oxide (NO) donor moieties were attached directly to an aryl carbon on a celecoxib template. The percentage of NO rel