A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2diolato ammonium salt, and its O 2 -methyl and O 2 -acetoxyethyl derivatives, nitric oxide (NO) donor moieties were attached directly to an aryl carbon on a celecoxib template. The percentage of NO rel
✦ LIBER ✦
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies
✍ Scribed by Khaled R.A. Abdellatif; Morshed Alam Chowdhury; Ying Dong; Dipankar Das; Gang Yu; Carlos Velázquez; Mavanur R. Suresh; Edward E. Knaus
- Book ID
- 108072651
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 410 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0968-0896
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Celecoxib prodrugs possessing a diazen-1
✍
Khaled R.A. Abdellatif; Morshed A. Chowdhury; Carlos A. Velázquez; Zhangjian Hua
📂
Article
📅
2010
🏛
Elsevier Science
🌐
English
⚖ 284 KB
Syntheses, calcium channel modulation ef
✍
Carlos Velazquez; Dean Vo; Edward E. Knaus
📂
Article
📅
2003
🏛
John Wiley and Sons
🌐
English
⚖ 152 KB
A group of racemic 4-aryl(heteroary)-1,4-dihydro-2,6-dimethyl-3-nitropyridine-5-carboxylates possessing a potential nitric oxide donor C-5 O 2 -alkyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate ester [alkyl ¼ (CH 2 ) n , n¼ 1-4] substituent were synthesized using a modified Hantzsch reaction. Compou